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Trustworthy Decision-Making for Autonomous Vehicles: A Robust Reinforcement Learning Approach with Safety

Xiangkun He,Wenhui Huang,Chen Lv,

Engineering doi: 10.1016/j.eng.2023.10.005

Abstract: Therefore, we present a novel robust reinforcement learning approach with safety guarantees to attainThe proposed technique ensures decision trustworthiness in terms of policy robustness and collision safetyMoreover, we devise a safety mask to guarantee the collision safety of the autonomous driving agent duringand testing processes using an interpretable knowledge model known as the Responsibility-Sensitive Safetyagent can make trustworthy decisions and drastically reduce the number of collisions through robust safety

Keywords： Autonomous vehicle Decision-making Reinforcement learning Adversarial attack Safety guarantee

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Safety Guarantee Measures for Subsea Shield Tunnel Segments Based on Life Cycle Deterioration Analysis

Liu Sijin,He Chuan,Sun Qi and Feng Kun

Strategic Study of CAE 2017, Volume 19, Issue 6, Pages 52-60 doi: 10.15302/J-SSCAE-2017.06.008

Abstract: If its performance deteriorates, it will seriously affect the safety of the lining structure of entireand deterioration over the entire life cycle, economic and rational measures to ensure the long-term safety

Keywords： shield tunnel safety guarantee deterioration analysis ion erosion segment joint

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Safety of Highway Bridges in China

Zhou Jianting and Zheng Dan

Strategic Study of CAE 2017, Volume 19, Issue 6, Pages 27-37 doi: 10.15302/J-SSCAE-2017.06.005

Abstract: ="text-align: justify;">With the continuous increase in bridge service life, problems regarding the safetySafety guarantee issues will become increasingly prominent.In this study, the current safety situation and trends in bridge structure are investigated, along withThe present situation of bridges in China in the field of safety and its challenges are also discussedFurthermore, policies, technologies, and measures for bridge safety and security are proposed.

Keywords： highway bridge safety guarantee technology

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Wind Resistance Safety of Marine Bridge Engineering and Corresponding Guarantee Countermeasures

Liao Haili , Li Mingshui , Zhou Qian

Strategic Study of CAE 2019, Volume 21, Issue 3, Pages 12-17 doi: 10.15302/J-SSCAE-2019.03.012

Abstract: long-span bridges, the wind field of marine bridges will be more complicated, and their wind resistance safetydesign theories, countermeasures for wind-induced vibration, and windbreak technologies for driving safetyBased on these analyses, countermeasures for guaranteeing wind resistance safety of marine bridges are

Keywords： marine bridge engineering wind resistance safety typhoon aerodynamic countermeasures

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Reliability guarantee framework for the Sichuan–Tibet Railway

Frontiers of Engineering Management 2021, Volume 8, Issue 4, Pages 480-491 doi: 10.1007/s42524-021-0170-4

Abstract: Consequently, countermeasures are necessary and urgent to ensure its safety and reliability in the wholeThis study proposes a novel reliability framework to guarantee the ideal operation state of the Sichuan–Tibetfact that the Sichuan–Tibet Railway is a complex giant system, Nine-Connotation was summarized (i.e., safetyof the railway’s giant complex system, innovating and establishing the management principle of great safety

Keywords： Sichuan–Tibet Railway operational efficiency reliability guarantee Nine-Connotation implementation

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Discussion on Long-Life Security Strategies for Railway Track Engineering

Wang Ping,Chen Rong and An Boyang

Strategic Study of CAE 2017, Volume 19, Issue 6, Pages 66-71 doi: 10.15302/J-SSCAE-2017.06.010

Abstract: progress in the development of rail transportation infrastructure has been achieved in China, operational safetyCompared to developed countries, current research into long-life safety in the field of railway track

Keywords： railway track engineering long life safety guarantee Shift2Rail

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Eutrophication Control of Lake/Reservoir Water Sources and Assurance of Drinking Water Safety in China

Cao Xiaofeng, Ji Zehua, Lan Huachun, Liu Huijuan, Qu Jiuhui

Strategic Study of CAE 2022, Volume 24, Issue 5, Pages 34-40 doi: 10.15302/J-SSCAE-2022.05.005

Abstract: and cyanobacterial bloom against the background of global climate change, which threatens the safetychallenges from the aspects of water source protection, purification process, pipe network distribution, and guaranteeFour targeted suggestions were recommended for guaranteeing drinking water safety: (1) strengtheningpromoting the construction of a scientific and technological support system for guaranteeing drinking water safetyaccelerating the system and mechanism innovation for guaranteeing lake and reservoir drinking water safety

Keywords： climate change drinking water safety guarantee lake and reservoir eutrophication

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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 322-338 doi: 10.1007/s11684-021-0901-2

Abstract: Immune-based therapies have experienced a pronounced breakthrough in the past decades as they acquired multiple US Food and Drug Administration (FDA) approvals for various indications. To date, six chimeric antigen receptor T cell (CAR-T) therapies have been permitted for the treatment of certain patients with relapsed/refractory hematologic malignancies. However, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or they reported life-threatening treatment-related damages to healthy tissues. The simultaneous expression of target antigens by healthy organs and tumor cells is partly responsible for such toxicities. Alongside targeting tumor-specific antigens, targeting the aberrantly glycosylated glycoforms of tumor-associated antigens can also minimize the off-tumor effects of CAR-T therapies. Tn, T, and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis, and their expression results from the dysregulation of a series of glycosyltransferases and the endoplasmic reticulum protein chaperone, Cosmc. Moreover, these glycoforms have been associated with various types of cancers, including prostate, breast, colon, gastric, and lung cancers. Here, we discuss how underglycosylated antigens emerge and then detail the latest advances in the development of CAR-T-based immunotherapies that target some of such antigens.

Keywords： cancer immunotherapy chimeric antigen receptor solid tumors tumor-associated antigen glycosylation O-glycans adoptive cell therapy

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Research on the Strategies for Safe Management of Drinking Water in the Yangtze River Delta

Chu Wenhai , Yang Xu , Xiao Rong , Jin Wei

Strategic Study of CAE 2022, Volume 24, Issue 5, Pages 19-25 doi: 10.15302/J-SSCAE-2022.05.003

Abstract:

The safety of drinking water is related to the national economy and theThe Chinese government has always attached great importance to the safety guarantee of drinking waterAfter more than ten years of development, the overall level of drinking water safety assurance in theHowever, the people's requirements for water quality safety and health are also gradually improving, and the drinking water safety assurance work of the Yangtze River Delta Megalopolis is still facing

Keywords： drinking water Yangtze Delta safety guarantee micro-pollutants emerging contaminants green development

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Service Security of Underwater Tunnel Lining Structures and Corresponding Guarantee Countermeasures

He Chuan,Liu Sijin,Zhang Yuchun and Feng Kun

Strategic Study of CAE 2017, Volume 19, Issue 6, Pages 44-51 doi: 10.15302/J-SSCAE-2017.06.007

Abstract:

This paper analyzes four aspects of the safety problems in tunnel lining

Keywords： underwater tunnels service security security guarantee countermeasures long life structural defects

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Genetic Crop Improvement: A Guarantee for Sustainable Agricultural Production

Jianmin Wan

Engineering 2018, Volume 4, Issue 4, Pages 431-432 doi: 10.1016/j.eng.2018.07.019

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“Heavenly Road”: The Qinghai–Tibet Railway

Yongfu SUN

Frontiers of Engineering Management 2020, Volume 7, Issue 2, Pages 304-307 doi: 10.1007/s42524-019-0079-3

Abstract: Xiaobo WANG. [J]. Front. Eng, 2019, 6(1): 131-137.Peter REDFERN, Hua ZHONG. [J]. Front. Eng, 2017, 4(2): 193-200.Qixiang FAN. [J]. Front. Eng, 2017, 4(2): 231-237.Ming-zhou Liu,Cong-hu Liu,Mao-gen Ge,Yuan Zhang,Qing-hua Zhu. [J]. Front. Eng, 2016, 3(2): 144-146.Yu Zhao,Sheng-quan Wang,Ke-chao Zhu. [J]. Front. Eng, 2015, 2(1): 35-38.Ru-gui Chen,Jia-meng Chen. [J]. Front. Eng, 2014, 1(1): 52-61.An Wang. [J]. Front. Eng, 2014, 1(1): 13-17.

Keywords： permafrost protection sustainable development health guarantee system

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Urban design based on public safety-Discussion on safety-based urban design

Kaizhen CAI, Jianguo WANG

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 2, Pages 219-227 doi: 10.1007/s11709-009-0023-4

Abstract: Because of public safety problems in construction of urban surroundings, this paper expounds the necessityof the study on public safety-based urban design in perspective of modern city.It brings forward the concept of safety-based urban design and attempts to explore the basic connotation

Keywords： urban public safety urban design safety-based urban design

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Study on the Priority of Food Safety Science and Technology in China

Wei Yimin,Wu Yongning,Zhou Naiyuan,Pan Jiarong

Strategic Study of CAE 2005, Volume 7, Issue 11, Pages 1-4

Abstract: its focus on food quality and safety, while developing economy.This paper, from the angle of developing national food safety strategy and strengthening food safetyis the scientific basis of food safety, and risk assessment is the key technology of food safety, itis suggested to be the first priority of food safety strategy., all responsible parties should bear the responsibility for food quality and safety.

Keywords： food safety science and technology of food safety strategy of food safety priority of food safety

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Probabilistic safety assessment of self-centering steel braced frame

Navid RAHGOZAR, Nima RAHGOZAR, Abdolreza S. MOGHADAM

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 1, Pages 163-182 doi: 10.1007/s11709-017-0384-z

Abstract: states and investigates the seismic performance of self-centering braced frame using a Probabilistic SafetyMargin of safety, confidence level, and mean annual frequency of the self-centering archetypes for theirthat the design of low- and mid-rise self-centering archetypes could provide the adequate margin of safety

Keywords： self-centering steel braced frame mean annual frequency safety assessment confidence level margin ofsafety